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2010

Anticancer drugs from marine flora: an overview.
Sithranga Boopathy N, Kathiresan K.
J Oncol. 2010, 2010, 214186.

Brown alga Ecklonia cava attanuates type 1 diabetes by activation AMPK and Ark signaling pathways.
Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E.
Food Chem Toxicol. 2010, 48(2), 509-516.

Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells.
Lee SH, Han JS, Heo SJ, Hwang JY, Jeon YJ.
Toxicol In Vitro. 2010, 24(2), 375-381.

Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt.
Kim KC, Kang KA, Zhang R, Piao MJ, Kim GY, Kang MY, Lee SJ, Lee NH, Surh YJ, Hyun JW.
Int J Biochem Cell Biol. 2010, 42(2), 297-305.

Cytoprotective effects of triphlorethol-A against formaldehyde-induced oxidative damage and apoptosis: role of mitochondria-mediated caspase-dependent pathway.
Zhang R, Lee IK, Kang KA, Piao MJ, Kim KC, Kim BJ, Lee NH, Choi JY, Choi J, Hyun JW.
J Toxicol Environ Health A. 2010, 73(21-22), 1477-1489.

Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava.
Zhang C, Li Y, Shi X, Kim SK.
BMB Rep. 2010, 43(1), 62-68.

Phlorotannins from Ecklonia cava (Phaeophyceae): biological activities and potential health benefits.
Wijesekara I, Yoon NY, Kim SK.
Biofactors. 2010, 36(6), 408-414.

Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression.
Park E, Ahn G, Yun JS, Kim MJ, Bing SJ, Kim DS, Lee J, Lee NH, Park JW, Jee Y.
Int J Radiat Biol. 2010, 86(10), 848-859.

Effect of Supplementation With Ecklonia cava Polyphenol on Endurance Performance of College Students.
Oh JK, Shin YO, Yoon JH, Kim SH, Shin HC, Hwang HJ.
Int J Sport Nutr Exerc Metab. 2010, 20(1), 72-79.

Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice.
Lee SH, Park MH, Heo SJ, Kang SM, Ko SC, Han JS, Jeon YJ.
Food Chem Toxicol. 2010, 48(10), 2633-2637.

Protective effects of enzymatic digest from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells.
Lee SH, Heo SJ, Hwang JY, Han JS, Jeon YJ.
J Sci Food Agric. 2010, 90(2), 349-356.

Antifungal Activities of Dieckol Isolated from the Marine Brown Alga Ecklonia cava against Trichophyton rubrum.
Lee MH, Lee KB, Oh SM, Lee BH, Chee HY.
J Korean Soc Appl Biol Chem. 2010, 53(4), 504-507.

Ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells
Kim TH, Bae JS.
Food Chem Toxicol. 2010, 48(6), 1682-1687.

Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes.
Kim SK, Kong CS.
Chem Biol Interact. 2010, 186(1), 24-29.

Effect of phloroglucinol on oxidative stress and inflammation.
Kim MM, Kim SK.
Food Chem Toxicol. 2010, 48(10), 2925-2933.

Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo.
Kang KA, Zhang R, Chae S, Lee SJ, Kim J, Kim J, Jeong J, Lee J, Shin T, Lee NH, Hyun JW.
Chem Biol Interact. 2010, 185(3), 215-226.

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity.
Jung HA, Oh SH, Choi JS.
Bioorg Med Chem Lett . 2010, 20(11), 3211-3215.

Quantitative determination of major phlorotannins in Ecklonia stolonifera.
Goo HR, Choi JS, Na DH.
Arch Pharm Res. 2010, 33(4), 539-544.

Antibacterial Activity of Ecklonia cava Against Methicillin-Resistant Staphylococcus aureus and Salmonella spp.
Choi JG, Kang OH, Brice OO, Lee YS, Chae HS, Oh YC, Sohn DH, Park H, Choi HG, Kim SG, Shin DW, Kwon DY.
Foodborne Pathog Dis. 2010, 7(4), 435-441.

1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts.
Kong CS, Kim JA, Ahn BN, Vo TS, Yoon NY, Kim SK.
Mar Biotechnol (NY). 2010, 12(3), 299-307.

2009

Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties.
Kim AR, Shin TS, Lee MS, Park JY, Park KE, Yoon NY, Kim JS, Choi JS, Jang BC, Byun DS, Park NK, Kim HR.
J Agric Food Chem. 2009, 57(9), 3483-3489.

Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava.
Li Y, Qian ZJ, Ryu B, Lee SH, Kim MM, Kim SK.
Bioorg Med Chem. 2009, 17(5), 1963-1973.

Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on FcepsilonRI expression.
Shim SY, Choi JS, Byun DS.
Bioorg Med Chem. 2009, 17(13), 4734-4739.

Anti-allergic effects of ethanol extracts from brown seaweeds.
Samee H, Li ZX, Lin H, Khalid J, Guo YC.
J Zhejiang Univ Sci B. 2009, 10(2), 147-153.

Ecklonia cava extract suppresses the high-affinity IgE receptor, FcepsilonRI expression.
Shim SY, Quang-To L, Lee SH, Kim SK.
Food Chem Toxicol. 2009, 47(3). 555-560.

Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells.
Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, Choi IW.
J Agric Food Chem. 2009, 57(10), 4439-4446.

Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kB pathways.
Jung WK, Ahn YW, Lee SH, Choi YH, Kim SK, Yea SS, Choi I, Park AG, Seo SK, Lee SW, Choi IW.
Food Chem Toxicol. 2009, 47(2), 410-407.

Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells.
Kong CS, Kim JA, Yoon NY, Kim SK.
Food Chem Toxicol. 2009, 47(7), 1653-1658.

α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava.
Lee SH, Li Y, Karadeniz F, Kim MM, Kim SK.
J Sci Food Agric. 2009, 89(9), 1552-1558.

Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease.
Ryu B, Li Y, Qian ZJ, Kim MM, Kim SK.
Chem Biol Interact . 2009, 179(2-3), 192-201.

Matrix Metalloproteinase Inhibitors (MMPIs) from Marine Natural Products: the Current Situation and Future Prospects.
Zhang C, Kim SK.
Mar Drugs. 2009, 7(2), 71-84.

MMT Inhibitory Action of Seanol.
Saeki Y, NishiuraH, Tanaka K.
Fragrance J. 2009, 37, 94-96.

Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation.
Heo SJ, Ko SC, Cha SH, Kang DH, Park HS, Choi YU, Kim D, Jung WK, Jeon YJ.
Toxicol In Vitro. 2009, 23(6), 1123-1130.

Inhibitory efect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells.
Yoon NY, Eom TK, Kim MM, Kim SK.
J Agric Food Chem. 2009, 57(10), 4124-4129.

Inhibitory effects of polyphenols isolated from marine alga Ecklonia cava on histamine release.
Le QT, Li Y, Qian ZJ, Kim MM, Kim SK.
Process Biochemistry . 2009, 44(2), 168-176.